Anti-Heat-Labile Enterotoxin (HLT) LT-IIc Antibody
This rabbit polyclonal antibody was raised against protein and recognizes His-tagged LT-IIc, a type II heat-labile enterotoxin of Escherichia coli.
Highlights:
- Recognize both the A and B subunits of the toxin LT-IIc, a type II heat-labile enterotoxin
- Suitable for Western Blot and ELISA applications
LT-IIc is a type II heat-labile enterotoxin produced by certain strains of Escherichia coli. LT-IIc binds to gangliosides GM1, GM2, GM3, and GD1a, but has no detectable binding activity for GD1b, GQ1b, and GT1b, three gangliosides which are avidly bound by LT-IIa, another type II heat-labile entertoxin. LT-IIc binds to GM1, a ganglioside also bound by cholera toxin, a type I heat-labile enterotoxin, and by LT-IIa, but not by LT-IIb, the third member of the type II heat-labile enterotoxin family. The molecule induces high levels of cAMP in the cell upon intoxication. The enterotoxin is also a very strong mucosal and systemic adjuvant when administered by intranasal or intradermal routes.
From the laboratory of Terry D. Connell, PhD, University at Buffalo.
This rabbit polyclonal antibody was raised against protein and recognizes His-tagged LT-IIc, a type II heat-labile enterotoxin of Escherichia coli.
Highlights:
- Recognize both the A and B subunits of the toxin LT-IIc, a type II heat-labile enterotoxin
- Suitable for Western Blot and ELISA applications
LT-IIc is a type II heat-labile enterotoxin produced by certain strains of Escherichia coli. LT-IIc binds to gangliosides GM1, GM2, GM3, and GD1a, but has no detectable binding activity for GD1b, GQ1b, and GT1b, three gangliosides which are avidly bound by LT-IIa, another type II heat-labile entertoxin. LT-IIc binds to GM1, a ganglioside also bound by cholera toxin, a type I heat-labile enterotoxin, and by LT-IIa, but not by LT-IIb, the third member of the type II heat-labile enterotoxin family. The molecule induces high levels of cAMP in the cell upon intoxication. The enterotoxin is also a very strong mucosal and systemic adjuvant when administered by intranasal or intradermal routes.
From the laboratory of Terry D. Connell, PhD, University at Buffalo.
| Product Type: | Antibody |
| Antigen: | LT-llc |
| Molecular Weight: | 88 kDa |
| Clonality: | Polyclonal |
| Immunogen: | Protein |
| Species Immunized: | Rabbit |
| Buffer: | Antiserum |
| Tested Applications: | WB (1:5,000 - 1:20,000) |
| Comments: | Hyperimmune antiserum |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Hesham F. Nawar, Sergio Arce, Michael W. Russell and Terry D. Connell. 2005. Mucosal Adjuvant Properties of Mutant LT-IIa and LT-IIb Enterotoxins That Exhibit Altered Ganglioside-Binding Activities. Infect. Immun. 73(3):1330-1342.
If you publish research with this product, please let us know so we can cite your paper.
