Cyclic diguanosine monophosphate (c-di-GMP) produced from Agrobacterium vitis protein engineered Diguanylate Cyclase over-expressed in Escherichia coli.
Cyclic-di-GMP is a second messenger used in signal transduction in bacteria, important in studies of bacterial virulence, bacterial infectiousness, pathogenesis, vaccine adjuvants (potentially in MRSA vaccines), innate immunity response, bacterial biofilm formation, bacterial cell-cell interactions, and bacterial cell adhesion. Biological activity regulated by cyclic-di-GMP is mediated through binding to many different receptors. Additionally, it has been more recently shown that cyclic-di-GMP induces the production of type I interferons in a STING or DDX41 dependent manner in the mammalian innate immune system.
From the laboratory of Elizabeth M. Boon, PhD, Stony Brook University.
|Product Type:||Small Molecule|
|Name:||Cyclic Diguanosine Monophosphate (c-di-GMP)|
|Alternative Name(s):||Cyclic diguanylate, 3',5'-Cyclic diguanylic acid, c-di-GMP, cyclic di-GMP|
|Molecular Weight:||690.09 g/mol|
|Spectral Information:||Absorbance 260|
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