Beta Tubulin Type II [7B9] Antibody

This IgG mouse antibody was generated against the C-terminus of beta II tubulin (CEEEEGEDEA) and recognizes mammalian homologs.

Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of alpha and beta tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use.

Class II beta tubulin is the major form of tubulin beta in neurons, although it is not neuronal specific. It is found in many other tissues including lung tissue and Schwann cells. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a nonexchangeable site on the alpha chain.

From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Beta Tubulin Type II [7B9] Antibody
100ug 4-6 weeks
Regular Price:$355.00
On Sale:

Product Type: Antibody
Accession ID: Q13885
Isotype: IgG
Clonality: Monoclonal
Clone Name: 7B9
Specificity: Class II Beta Tubulin (all mammalian homologs)
Immunogen: Generated against C-terminus of Class II Beta Tubulin (CEEEEGEDEA)
Species Immunized: Mouse
Purification Method: Protein A/G Chromatography
Tested Applications: WB, IF, IP
Storage: -20C
Shipped: Cold packs


Dot blot of b-tubulin peptides and isotype-specific monoclonal antibodies. Tubulin carboxyl-terminal peptides were transferred to PVDF and reacted with isotype-specific monoclonal antibodies. Equal quantities of peptide sequences shown (right) were applied to the blot.

Adapted from: Lobert S, Frankfurter A, Correa JJ. Energetics of vinca alkaloid interactions with tubulin isotypes: implications for drug efficacy and toxicity. Methods Cell Motil Cytoskeleton. 39(2):107-121, (1998).

From the laboratories of Anthony Frankfurter, PhD and Anthony Spano, PhD, University of Virginia.
  1. Moody SA, Miller V, Spanos A, Frankfurter A. Developmental expression of a neuron-specific beta-tubulinn in frog (Xenopus laevis): a marker fro growing axons during the empryonic period. J Comp Neurol. 8;364(2):219-230, (1996).

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