Anti-BMAL-1 Antibody
This rabbit polyclonal antibody was generated against peptide and recognizes all species aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL-1).
Highlights:
- Reacts with all species BMAL-1
- Suitable for Western Blot and Immunoprecipitation applications
The BAML-1 protein is basic helix-loop-helix protein that forms a heterodimer with CLOCK and is involved in circadian rhythms. Once the heterodimer forms it binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. Mutations in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns.
From the laboratory of Carrie L. Partch, PhD, University of California, Santa Cruz.
This rabbit polyclonal antibody was generated against peptide and recognizes all species aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL-1).
Highlights:
- Reacts with all species BMAL-1
- Suitable for Western Blot and Immunoprecipitation applications
The BAML-1 protein is basic helix-loop-helix protein that forms a heterodimer with CLOCK and is involved in circadian rhythms. Once the heterodimer forms it binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. Mutations in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns.
From the laboratory of Carrie L. Partch, PhD, University of California, Santa Cruz.
| Product Type: | Antibody |
| Accession ID: | O00327 |
| Antigen: | BMAL-1 |
| Clonality: | Polyclonal |
| Reactivity: | Universal / All Species |
| Immunogen: | Peptide 100% conserved |
| Species Immunized: | Rabbit |
| Epitope: | Last 25 amino acids |
| Buffer: | Titer Serum |
| Tested Applications: | WB, IP |
| Storage: | -80C |
| Shipped: | Cold Packs (Domestic, Overnight); Dry Ice (International) |
- Gustafson CL, Parsley NC, Asimgil H, Lee HW, Ahlbach C, Michael AK, Xu H, Williams OL, Davis TL, Liu AC, Partch CL. A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms. Mol Cell. 2017 May 18;66(4):447-457.e7.
- Xu H, Gustafson CL, Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC, Partch CL. Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus. Nat Struct Mol Biol. 2015 Jun;22(6):476-484.
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