This rabbit polyclonal antibody was generated against peptide and recognizes all species aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL-1).
The BAML-1 protein is basic helix-loop-helix protein that forms a heterodimer with CLOCK and is involved in circadian rhythms. Once the heterodimer forms it binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. Mutations in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns.
From the laboratory of Carrie L. Partch, PhD, University of California, Santa Cruz.
|Reactivity:||Universal / All Species|
|Immunogen:||Peptide 100% conserved|
|Epitope:||Last 25 amino acids|
|Tested Applications:||WB, IP|
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