Reversible Fluorescent Fe3+ Sensor (RPE)

RPE is a highly selective, sensitive and reversible off-on fluorescent Fe3+ sensor which can selectively image native Fe3+ in live cells.


  • Allows for viewing of endogenous exchangeable Fe3+ pools at sub-cellular resolution
  • Unique reversible "turn-on" property and high sensitivity
  • Little interference from other biologically relevant metal ions

RPE is a highly sensitive, highly selective and reversible turn-on fluorescent Fe3+ sensor. The sensor readily detects endogenous chelatable Fe3+ in live human SH-SY5Y cells at subcellular resolution in real time. The sensor gives a distinct rapid and reversible fluorescence response upon the alteration of intracellular Fe3+ levels with little interference from other biologically relevant metal ions.

From the laboratory of Maolin Guo, PhD, University of Massachusetts Dartmouth.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Reversible Fluorescent Fe3+ Sensor (RPE)
1mg Currently unavailable
Regular Price:$230.00
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Product Type: Small Molecule
Name: Methyl 6-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)picolinate (RPE)
Chemical Formula: C35H36N4O4
Molecular Weight: 576
Format: Off-white solid
Purity: >95%
Solubility: DMSO, DMF, EtOH, ACN, etc.
Spectral Information: NMR, MS
Platform: Fluorescence microscope
Compatible Cells: Mammalian cells
Detection Method: Fluorescence (excitation: 510-580 nm; emission: 550-700 nm)
Comments: Avoid exposure to light; Suggested amount per experiment: 10 μM (or 0.1 μg)
Storage: -20C to -80C
Shipped: Dry ice

From the laboratory of Maolin Guo, PhD, University of Massachusetts Dartmouth.
  1. Wei Y, Aydin Z, Zhang Y, Liu Z, Guo M. A turn-on fluorescent sensor for imaging labile Fe(3+) in live neuronal cells at subcellular resolution. Chembiochem. 2012 Jul 23;13(11):1569-73. doi: 10.1002/cbic.201200202. Epub 2012 Jun 26. PubMed PMID: 22736480.

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