DHSA-1426 is a canine hemangiosarcoma cell line derived from a tumor in the spleen of a 10-year old neutered male Golden Retriever. The cell line was derived from material obtained during a therapeutic splenectomy. This cell line grows in vitro, and it reproducibly forms hemangiosarcoma xenografts in immunodeficient mice when injected subcutaneously in Matrigel.
Hemangiosarcoma is a rapidly growing, highly invasive variety of cancer, occurring commonly in dogs. It is a sarcoma arising from the lining of blood vessels. A frequent cause of death is the rupturing of this tumor, causing the patient to rapidly bleed to death.
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
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|Product Type:||Cell Line|
|Source:||Spleen, The cell line was derived from material obtained during a therapeutic splenectomy.|
|Growth Conditions:||Ham's F12, 10% FBS, 0.05mg/ml ECGS, 0.01mg/ml heparin, 10mM HEPES Buffer, 100ug/ml Primocin|
|Subculturing:||Doubling time approx. 24 hours, Split 1:3-1:5 when cells reach ~80% confluence.|
|Comments:||This cell line grows in vitro, and it reproducibly forms hemangiosarcoma xenografts in immunodeficient mice when injected subcutaneously in Matrigel.|