Morphinan N-demethylase (MND), isolated from novel strain of Methylobacterium and produced recombinantly in E. coli.
Morphinan N-demethylase (MND) is a versatile morphinan N-demethylase isolated from a novel strain of Methylobacterium that is able to N-demethylate a broad substrate range with varying efficiencies but converts morphinan substrates such as morphine, thebaine and codeine most efficiently. Other compound classes N-demethylated by MND including benzylisoquinoline, galanthamine, and tropane alkaloids.
From the laboratory of Toni M. Kutchan, PhD and Megan Augustin, Donald Danforth Plant Science Center.
|Name:||Morphinan N-demethylase (MND)|
|Source:||Isolated from a novel strain of Methylobacterium and produced in E. coli|
|Molecular Weight:||74,237 Da|
|Purity:||Purified using HIS tag|
|Buffer:||50 mM potassium phosphate pH 8.0/ 10% glycerol|
|Concentration:||~0.5 mg/mL *Protein concentration provided does not include the GroEL protein.|
|Comments:||Morphinan N-demethylase (MND) is produced in E. coli cells along with the GroEL/GroES chaperone proteins and purified using His-tag. GroEL is co-purified with MND. Protein concentration provided does not include the GroEL protein.|
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