This mouse IgG monoclonal antibody was raised against purified GST-double-stranded RNA-specific editase 1 (ADAR2a) fusion protein (N-terminal Region, Amino Acids 2-179) and recognizes human and mouse ADAR2.
ADAR2 or ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
|Accession ID:||NCBI Gene ID: 104, Protein Accession No.: NP 056648|
|Antigen:||ADAR2 (ADARB1; adenosine deaminase, RNA specific B1)|
|Molecular Weight:||90 kDa|
|Specificity:||Native and Recombinant ADAR2; does not cross-react with different members of the ADAR family|
|Reactivity:||Human and mouse|
|Immunogen:||N-terminal, raised Against Purified GST-ADAR2a Fusion Protein (N-terminal Region, Amino Acids 2-179)|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, IHC, Immunostaining|
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