Anti-ADAR1 [15.8.6] Antibody
![Anti-ADAR1 [15.8.6] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1671_2001202001265716700.jpg "Anti-ADAR1 [15.8.6] Antibody")
This mouse IgG monoclonal antibody was raised against dsRNA binding domain (E2 to E8) of double-stranded RNA-specific adenosine deaminase (ADAR1) and recognizes human and mouse ADAR1.
Highlights:
- Reacts with human and mouse ADAR1
- Does not cross-react with different members of the ADAR family
- Suitable for Western Blot, Immunohistochemistry and Immunostaining applications
ADAR/ADAR1 encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
This mouse IgG monoclonal antibody was raised against dsRNA binding domain (E2 to E8) of double-stranded RNA-specific adenosine deaminase (ADAR1) and recognizes human and mouse ADAR1.
Highlights:
- Reacts with human and mouse ADAR1
- Does not cross-react with different members of the ADAR family
- Suitable for Western Blot, Immunohistochemistry and Immunostaining applications
ADAR/ADAR1 encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
Specifications
| Product Type: | Antibody |
| Antigen: | ADAR1 (adenosine deaminase, RNA specific) |
| Accession ID: | P55265 |
| Molecular Weight: | 110 kDa |
| Isotype: | IgG |
| Clonality: | Monoclonal |
| Clone Name: | 15.8.6 |
| Reactivity: | Human and mouse |
| Specificity: | Native and Recombinant ADAR1; does not cross-react with different members of the ADAR family |
| Immunogen: | dsRNA binding domain (E2 to E8); raised against middle region (E2 to E8) of ADAR1 protein |
| Species Immunized: | Mouse |
| Purification Method: | Protein G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB, IHC, Immunostaining |
| Storage: | -20C |
| Shipped: | Cold Packs |
Provider
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
References
- Wang Q, Khillan J, Gadue P, Nishikura K. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science. 2000 Dec 1;290(5497):1765-8. PubMed PMID: 11099415.
- Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K. Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA. J Biol Chem. 2003 May 9;278(19):17093-102. Epub 2003 Mar 4. PubMed PMID: 12618436.
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