This mouse IgG monoclonal antibody was raised against dsRNA binding domain (E2 to E8) of double-stranded RNA-specific adenosine deaminase (ADAR1) and recognizes human and mouse ADAR1.
ADAR/ADAR1 encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
From the laboratory of Kazuko Nishikura, PhD, The Wistar Institute.
|Antigen:||ADAR1 (adenosine deaminase, RNA specific)|
|Accession ID:||NCBI Gene ID: 103, Protein Accession No.: AAH38227|
|Molecular Weight:||110 kDa|
|Reactivity:||Human and mouse|
|Specificity:||Native and Recombinant ADAR1; does not cross-react with different members of the ADAR family|
|Immunogen:||dsRNA binding domain (E2 to E8); raised against middle region (E2 to E8) of ADAR1 protein|
|Purification Method:||Protein G|
|Buffer:||PBS, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, IHC, Immunostaining|
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