This rat IgG2b monoclonal antibody was raised against full length CDNA, whole CD6-transfected NB2 cells and is specific for mouse T-cell differentiation antigen CD6.
T-cell differentiation antigen CD6 is a cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses. It has been shown to interact with ALCAM/CD166. Cd6 is found on the outer membrane of T-lymphocytes as well as some other immune cells. CD6 contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. It is important protein for continuation of T cell activation.
|Molecular Weight:||130 kDa|
|Purification Method:||Protein A/G|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||Flow Cytometry (1 µg detects CD6 in one million mouse splenocytes)|
Tissue distribution of mouse CD6 detected with anti-mCD6 mAb #34-3.
Panel A shows anti-CD6 co-staining CD3+ (top row) and CD5+ (bottom row) lymphocytes from peripheral blood, lymph node, spleen and thymus. Panel B shows CD6 expression on CD4+ (top row) or CD8+ (bottom row) T cells from peripheral blood, lymph node, spleen and thymus.
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