KmUD SUMO Protease

KmUD is a recombinant temperature- and stress-resistant SUMO protease (UD) domain of Kluyveromyces marxianus Ulp1.


  • Can be used to digest recombinant SUMO fusion protein and sumoylated proteins
  • Exhibits robust SUMO-processing properties under a variety of conditions that include oxidative stress (0.6% H202), heat stress (37C), and protein denaturing reagents (2M Urea)

Proteins from Klyveromyces marxianus exhibit superior stability when exposed to high temperature and chemical insults relative to their budding yeast orthologs. This makes KmUD uniquely suited for the digestion of sumoylated proteins under a variety of buffer and reaction conditions.

From the laboratory of Oliver Kerscher, PhD, College of William & Mary.

Catalog Number Product Size AVAILABILITY Price Qty
KmUD SUMO Protease
100 Units In stock
Regular Price:$99.00

Product Type: Protein
Name: kmUD
Accession ID: Based on NCBI Gene ID: 34714692
Source: Recombinant
Molecular Weight: 67240 Da
Fusion Tag(s): MBP and HIS6
Purity: 98%
Buffer: 25mM Tris-HCl, pH. 8.0, 1% NP-40, 250mM NaCl, 5mM TCEP, 50% glycerol
Concentration: 1 Unit/uL
Activity: 1 Unit will digest 5ug of recombinant SUMO-CAT in 1h at 30-37C
Suggested Amount per Experiment: 1 Unit KmUD/20 uL reaction containing 2-5ug of SUMO-CAT or substrate of choice
Comments: Can be removed from digestion reaction owing to HIS6-tag
Storage: -80C
Shipped: Dry Ice

From the laboratory of Oliver Kerscher, PhD, College of William & Mary
  1. Peek J, Harvey C, Gray D, Rosenberg D, Kolla L, Levy-Myers R, Yin R, McMurry JL, Kerscher O. SUMO targeting of a stress-tolerant Ulp1 SUMO protease. PLoS One. 2018 Jan 19;13(1):e0191391. doi: 10.1371/journal.pone.0191391.

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