This mouse IgG1 monoclonal antibody was generated against human E-cadherin (partial, amino acids 155-707) and recognizes human and dog cadherin-1 (CDH1).
Cadherin-1 is a member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Mutations in this gene have been shown to associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
From the laboratory of Barry M. Gumbiner, PhD, University of Virginia.
|Alternative Name(s):||CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD_antigen: CD324|
|Reactivity:||Human and dog|
|Immunogen:||Human E-cadherin (partial, amino acids 155-707)|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB, ELISA, IF(ICC), IP|
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