This mouse IgG2a monoclonal antibody was generated against human complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35) and recognizes human CR1.
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. The CR1 gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The protein is involved in cellular binding to particles and immune complexes that have activated complement. Decreases in protein expression or mutations in the gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.
From the laboratory of Ronald P. Taylor, PhD, University of Virginia.
|Antigen:||Complement receptor 1 (CR1; also known as C3b/C4b receptor or CD35)|
|Immunogen:||Human complement receptor 1|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||ELISA, IF|
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