Anti-Ceacam 1 [230/231] Antibody

This rabbit polyclonal antibody was generated against purified protein from mouse colon and is specific for mouse carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1).

Highlights:

  • Specific for mouse CEACAM1; Does not react with other species
  • Reacts with all mouse CEACAM1 isoforms that bear the N-terminal domain
  • Suitable for Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry applications

CEACAM1 (biliary glycoprotein) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a tumor growth inhibitor. This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19 and the mouse CEACAM1 gene is located on mouse chr. 7. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

From the laboratory of Nicole Beauchemin, PhD, McGill University.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EMG004
Anti-Ceacam 1 [230/231] Antibody
100uL In stock
Regular Price:$345.00
On Sale:
Specifications

Product Type: Antibody
Antigen: CEACAM1
Accession ID: P13688
Molecular Weight: Native protein: CEACAM1-L (58 kDa), CEACAM1-S (54 kDa)
Glycosylated proteins so MW depends on the tissue: colon (120 kDa), liver (110 kDa), neutrophils (160 kDa)
Clonality: Polyclonal
Clone Name: 230/231
Reactivity: Mouse
Immunogen: Purified protein from mouse colon
Species Immunized: Rabbit
Epitope: N-terminal domain only
Buffer: Serum
Tested Applications: WB (1:1000-1:5000), IP (3-5 ug of Ab for IP of CEACAM1 from 1 mg of total lysate protein from transfected cells), IF (1:500-1:800), IHC (1:250-1:500)
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Nicole Beauchemin, PhD, McGill University.

References
  1. Daniels E, Letourneau S, Turbide C, Kuprina N, Rudinskaya T, Yazova AC, Holmes KV, Dveksler GS, Beauchemin N. Biliary glycoprotein 1 expression during embryogenesis: correlation with events of epithelial differentiation, mesenchymal-epithelial interactions, absorption, and myogenesis. Dev Dyn. 1996 Jul;206(3):272-90.
  2. McCuaig K, Turbide C, Beauchemin N. mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule. Cell Growth Differ. 1992 Mar;3(3):165-74.

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