Anti-Bone Sialoprotein (BSP), A129-E272 [LF-120] Antibody

Anti-Bone Sialoprotein (BSP), A129-E272 [LF-120] Antibody

This rabbit IgG polyclonal antibody was generated against recombinant protein E. coli and recognizes human, monkey, pig, dog, and rat bone sialoprotein (BSP).

Highlights:

  • Recognizes human, monkey, pig, dog, and rat BSP- Epitope A129-E272
  • Suitable for Immunohistochemistry and Western Blot applications

Bone sialoprotein (BSP) is a component of tissues such as bone, dentin, cementum and calcified cartilage. BSP is a phosphorylated glycoprotein and has been found in cells such as osteoblasts and osteocytes. Bone sialoprotein could be a potential serum marker for monitoring bone remodelling.

From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH075-FP
Anti-Bone Sialoprotein (BSP), A129-E272 [LF-120] Antibody
100uL In stock
Regular Price:$355.00
On Sale:

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Specifications

Product Type: Antibody
Antigen: Bone Sialoprotein (BSP), human
Accession ID: P21815
Molecular Weight: 35148 Da
Clonality: Polyclonal
Clone Name: LF-120
Reactivity: Human, monkey, pig, dog, and rat (others not tested)
Immunogen: Recombinant E. coli
Species Immunized: Rabbit
Epitope: A129-E272
Buffer: Whole serum
Tested Applications: WB 1:2000, IHC 1:200
Storage: -80C
Shipped: Cold Packs (Domestic, Overnight); Dry Ice (International)

Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research.
References
  1. Fisher LW, Stubbs JT 3rd, Young MF. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop Scand Suppl. 1995 Oct;266:61-5. PubMed PMID: 8553864.
  2. Cheng SL, Shin CS, Towler DA, Civitelli R. A dominant negative cadherin inhibits osteoblast differentiation. J Bone Miner Res. 2000 Dec;15(12):2362-70.
  3. Fedarko NS, Fohr B, Robey PG, Young MF, Fisher LW. Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack. J Biol Chem. 2000 Jun 2;275(22):16666-72.
  4. Cinamon U, Kronenberg J, Benayahu D. Structural changes and protein expression in the mastoid bone adjacent to cholesteatoma. Laryngoscope. 2000 Jul;110(7):1198-203.
  5. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12.
  6. Yang R, Davies CM, Archer CW, Richards RG. Immunohistochemistry of matrix markers in Technovit 9100 New-embedded undecalcified bone sections. Eur Cell Mater. 2003 Dec 31;6:57-71
  7. Mrozik K, Gronthos S, Shi S, Bartold PM.A Method to Isolate, Purify, and Characterize Human Periodontal Ligament Stem Cells. 2016 Methods Mol Biol. 2017;1537:413-427.
  8. Zhang JH, Wang J, Tang J, Barnett B, Dickson J, Hahsimoto N, Williams P, Ma W, Zheng W, Yoneda T, Pageau S, Chen J. Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells. Anticancer Res. 2004 May-Jun;24(3a):1361-8. PubMed PMID: 15274296.
  9. Huang GT, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, Shi S. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A. 2010 Feb;16(2):605-15.
    10. Hosoya A, Hoshi K, Sahara N, Ninomiya T, Akahane S, Kawamoto T, Ozawa H. Effects of fixation and decalcification on the immunohistochemical localization of bone matrix proteins in fresh-frozen bone sections. Histochem Cell Biol. 2005 Jun;123(6):639-46. Epub 2005 Jun 7. PubMed PMID: 15940506.
  10. Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod. 2008 Feb;34(2):166-71. doi: 10.1016/j.joen.2007.11.021. PubMed PMID: 18215674; PubMed Central PMCID: PMC2714367.

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