Anti-Dentin Sialophosphoprotein (DSPP), mouse DSP domain [LF-153] Antibody

This rabbit IgG polyclonal antibody was generated against recombinant protein (E coli) and is specific for mouse Dentin Sialophosphoprotein (DSPP).

Highlights:

  • Recognizes mouse DSPP - Epitope N49 to Q362 (DSP domain)
  • Suitable for Immunohistochemistry and Western Blot applications

The two proteins dentin sialoprotein and dentin phosphoprotein are components of dentin, which is a bone-like substance that makes up the protective middle layer of each tooth. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1.

From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH083-FP
Anti-Dentin Sialophosphoprotein (DSPP), mouse DSP domain [LF-153] Antibody
100uL In stock
Regular Price:$306.00
On Sale:

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Specifications

Product Type: Antibody
Antigen: Dentin Sialophosphoprotein (DSPP), human
Accession ID: NP_034210.2
Molecular Weight: 94865 Da
Clonality: Polyclonal
Clone Name: LF-153
Reactivity: Mouse
Immunogen: Recombinant protein (E. coli)
Species Immunized: Rabbit
Epitope: N49 to Q362 (DSP domain)
Buffer: Whole serum
Tested Applications: WB 1:2000, IHC 1:300
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research.
References
  1. Amri N, Djolé SX, Petit S, Babajko S, Coudert AE, Castaneda B, Simon S, Berdal A. Distorted Patterns of Dentinogenesis and Eruption in Msx2 Null Mutants: Involvement of Sost/Sclerostin. Am J Pathol. 2016 Oct;186(10):2577-87.
  2. von Marschall Z, Fisher LW. Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1). Matrix Biol. 2010 May;29(4):295-303.
  3. von Marschall Z, Mok S, Phillips MD, McKnight DA, Fisher LW. Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP. J Bone Miner Res. 2012 Jun;27(6):1309-21.
  4. Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004 Apr 30;279(18):19141-8. Epub 2004 Feb 13. PubMed PMID: 14966118.
  5. Ogbureke KU, Fisher LW. Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res. 2004 Sep;83(9):664-70. PubMed PMID: 15329369.
  6. Suzuki S, Haruyama N, Nishimura F, Kulkarni AB. Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues. Arch Oral Biol. 2012 Sep;57(9):1165-75.
  7. Chu EY, Fong H, Blethen FA, Tompkins KA, Foster BL, Yeh KD, Nagatomo KJ, Matsa-Dunn D, Sitara D, Lanske B, Rutherford RB, Somerman MJ. Ablation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex. Anat Rec (Hoboken). 2010 Jul;293(7):1214-26.
  8. Suzuki S, Sreenath T, Haruyama N, Honeycutt C, Terse A, Cho A, Kohler T, Müller R, Goldberg M, Kulkarni AB. Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biol. 2009 May;28(4):221-9. doi: 10.1016/j.matbio.2009.03.006. Epub 2009 Apr 5. PubMed PMID: 19348940; PubMed Central PMCID: PMC2758621.

If you publish research with this product, please let us know so we can cite your paper.

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