Anti-CYE-1 [17C8] Antibody, (supernatant)

This mouse monoclonal antibody was generated against full-length recombinant cyclin E (CYE-1) protein and is specific for Caenorhabditis elegans CYE-1 full-length recombinant protein (prepared in bacteria).


  • Recognizes C. elegans CYE-1 full-length recombinant protein (prepared in bacteria)
  • Suitable for Immunofluorescence and Western Blot applications

Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin E–Cdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers.

From the laboratory of Edward T. Kipreos, PhD, University of Georgia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
Anti-CYE-1 [17C8] Antibody, (supernatant)
5 mL In stock
Regular Price:$336.00
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Product Type: Antibody
Accession ID: NM_001025857.2
Antigen: C. elegans CYE-1 full-length recombinant protein (prepared in bacteria)
Molecular Weight: 60.6 kDa
Clonality: Monoclonal
Clone Name: 17C8
Reactivity: C. elegans
Immunogen: Full-length recombinant CYE-1 protein
Species Immunized: Mouse
Purification Method: Not purified, available as antibody supernatant
Buffer: Cell culture supernatant
Tested Applications: Immunofluorscence (1:100-300) and Western Blot
Storage: -80C
Shipped: Dry Ice

From the laboratory of Edward T. Kipreos, PhD, University of Georgia.
  1. Brodigan, T.M., Liu, J., Park, M., Kipreos, E.T., and Krause, M. 2003. Cyclin E expression during development in C. elegans. Developmental Biology 254: 102-115.
  2. Kim, Y., and Kipreos, E.T. 2007. The C. elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Molecular and Cellular Biology 27: 1394-1406.
  3. The, I., Ruijtenberg, S., Bouchet, B. P., Cristobal, A., Prinsen, M. B., van Mourik, T., Koreth, J., Xu, H., Heck, A. J., Akhmanova, A., Cuppen, E., Boxem, M., Munoz, J., & van den Heuvel, S. (2015). Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nat Commun, 6, 5906.
  4. Fox, P. M., Vought, V. E., Hanazawa, M., Lee, M. H., Maine, E. M., & Schedl, T. (2011). Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development, 138 , 2223-34.
  5. Chiang, M., Cinquin, A., Paz, A., Meeds, E., Price, C. A., Welling, M., & Cinquin, O. (2015). Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation. BMC Biol, 13, 51.
  6. Korzelius, J., The, I., Ruijtenberg, S., Prinsen, M. B., Portegijs, V., Middelkoop, T. C., Groot, M. J. K., Holstege, F. C., Boxem, M., & van den Heuvel, S. (2011). Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. PLoS Genet, 7, e1002362.
  7. Friend, K., Campbell, Z. T., Cooke, A., Kroll-Conner, P., Wickens, M. P., & Kimble, J. (2012). A conserved PUF-Ago-eEF1A complex attenuates translation elongation. Nat Struct Mol Biol, 19, 176-83.
  8. Peel, N., Dougherty, M., Goeres, J., Liu, Y., & O'Connell, K. F. (2012). The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci, 125, 3535-44.

If you publish research with this product, please let us know so we can cite your paper.