Anti-Collagen Alpha-1(I) Chain Carboxy-Telopeptide [LF-68] Antibody

This rabbit IgG polyclonal antibody was raised against peptide and recognizes human and other species type 1 collagen alpha-1 carboxy telopeptide.

Highlights:

  • Recognizes human and other species type 1 collagen alpha-1 carboxy telopetide - Epitope - amino acid sequence SAGFDFSFLPQPPQEKAHDGGRYYRA
  • Suitable for Immunohistochemistry and Western Blot applications

Collagen is a protein that supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). Specifically collagen type 1 alpha 1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Mutations in the gene can cause ostegensis imperfecta and ehlers-danlos syndrome.

From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ENH018-FP
Anti-Collagen Alpha-1(I) Chain Carboxy-Telopeptide [LF-68] Antibody
100uL In stock
Regular Price:$306.00
On Sale:

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Specifications

Product Type: Antibody
Accession ID: NP_000079
Antigen: Type I collagen alpha-1 carboxy-telopeptide
Molecular Weight: 136514 Da
Isotype: IgG
Clonality: Polyclonal
Clone Name: LF-68
Reactivity: Human and most other species
Immunogen: Peptide
Species Immunized: Rabbit
Epitope: SAGFDFSFLPQPPQEKAHDGGRYYRA
Buffer: Whole serum
Tested Applications: WB (1:2000), IHC (1:400)
Storage: -80C
Shipped: Dry Ice

Provider
From the laboratory of Larry W. Fisher, PhD, National Institute of Dental and Craniofacial Research/NIH.
References
  1. Fisher LW, Stubbs JT 3rd, Young MF. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop Scand Suppl. 1995 Oct;266:61-5.
  2. Bonfanti L, Mironov AA Jr, Martínez-Menárguez JA, Martella O, Fusella A, Baldassarre M, Buccione R, Geuze HJ, Mironov AA, Luini A. Procollagen traverses the Golgi stack without leaving the lumen of cisternae: evidence for cisternal maturation. Cell. 1998 Dec 23;95(7):993-1003.
  3. Martínez-Glez V, Valencia M, Caparrós-Martín JA, Aglan M, Temtamy S, Tenorio J, Pulido V, Lindert U, Rohrbach M, Eyre D, Giunta C, Lapunzina P, Ruiz-Perez VL. Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta. Hum Mutat. 2012 Feb;33(2):343-50. doi: 10.1002/humu.21647.
  4. Liu X, Cao M, Palomares M, Wu X, Li A, Yan W, Fong MY, Chan WC, Wang SE. Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res. 2018 Oct 22;20(1):127. View Article
  5. Marconi A, Hancock-Ronemus A, Gillis JA. Adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea. Elife. 2020;9:e53414. Published 2020 May 12. View Article 
  6. Zhao X, Pan J, Li W, Yang W, Qin L, Pan Y. Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. Int J Nanomedicine. 2018;13:6207-6221. Published 2018 Oct 9. View Article

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