pCS2-SENP2(L) Plasmid

pCS2-SENP2(L) plasmid is a vector encoding the Senp2 gene for SUMO-specific protease 2.


  • Expresses the long isoform of SUMO-specific protease 2 (SENP2)
  • Driven by a CMV promoter
  • The SENP2 protein is fused to a myc tag

pCS2-SENP2(L) is a plasmid containing cDNA which encodes the long isoform of myc tagged SENP2. The expression is driven by CMV promoter. SENP2 encodes SUMO-specific protease 2 which is found in three alternatively spliced forms exhibiting differential subcellular localizations. Genetic inactivation of Senp2 in mice reveals its requirement in development of trophoblast stem cell niches and lineages during development of the placenta. The deletion of SENP2 in the neural progenitors results in neural degeneration mediated through modulation of Drp1-dependent mitochondrial morphogenesis.

From the laboratory of Wei Hsu, PhD, University of Rochester.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
pCS2-SENP2(L) Plasmid
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Product Type: Plasmid
Gene/insert name: SENP2-L
Accession ID: Q9HC62
Antibiotic Resistance: Amp
Fusion Tag(s): Myc tag
Grow in E. coli at 37 C: Yes
Selectable markers: Amp
Cloning Site 5': Xho l
Cloning Site 3': Xba I
Insert Size: 1764 bp
Vector Backbone and Size: 4352 Kb
High or low copy: High
Storage: -20C
Shipped: Ambient temperature as liquid



CMV driven expression of SENP2 long isoform.

From the laboratory of Wei Hsu, PhD, University of Rochester.
  1. Jiang, M., S.Y. Chiu, and W. Hsu, SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ, 2011. 18(6): p. 1005-15.
  2. Chiu, S.Y., N. Asai, F. Costantini, and W. Hsu, SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages. PLoS Biol, 2008. 6(12): p. e310.
  3. Fu, J., H.M. Yu, S.Y. Chiu, A.J. Mirando, E.O. Maruyama, J.G. Cheng, and W. Hsu, Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration. PLoS Genet, 2014. 10(10): p. e1004579.

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