This hamster IgG1 monoclonal antibody was generated against recombinant mouse TNF-like ligand 1A (TL1A), and is specific for mouse TL1A.
TNF-like ligand 1A (TL1A), also known as Vascular endothelial growth inhibitor (VEGI) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. The protein belongs to the tumor necrosis factor ligand superfamily, and is a receptor for TNFRSF25 and TNFRSF6B. TL1A mediates activation of NF-kappa-B, and inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis pathways, and is found in endothelial cells but not in B or T cells. TL1Apromotes splenocyte alloactivation. In clinical studies, it has been shown to be strongly associated with inflammatory bowel disease.
From the laboratory of Eckhard R. Podack, MD, PhD, University of Miami.
|Alternative Name(s):||Vascular endothelial growth inhibitor (VEGI), TNF superfamily member 15 (TNFSF15)|
|Antigen:||TL1A-TNF-like ligand 1A|
|Immunogen:||MTL1A-MBP (Maltose Binding Protein), Freund's complete and incomplete adjuvant|
|Species Immunized:||Armenian Hamster|
|Epitope:||Blocks binding to TNFRSF25|
|Purification Method:||Protein G|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||ELISA, FACS and Biological Function|
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