Anti-TL1A [L4G6] Antibody

This hamster IgG1 monoclonal antibody was generated against recombinant mouse TNF-like ligand 1A (TL1A), and is specific for mouse TL1A.

Highlights:

  • Reacts with mouse TL1A (epitope: Blocks binding to tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
  • Suitable for FACS, ELISA and Biological Function applications

TNF-like ligand 1A (TL1A), also known as Vascular endothelial growth inhibitor (VEGI) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. The protein belongs to the tumor necrosis factor ligand superfamily, and is a receptor for TNFRSF25 and TNFRSF6B. TL1A mediates activation of NF-kappa-B, and inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis pathways, and is found in endothelial cells but not in B or T cells. TL1Apromotes splenocyte alloactivation. In clinical studies, it has been shown to be strongly associated with inflammatory bowel disease.

From the laboratory of Eckhard R. Podack, MD, PhD, University of Miami.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EMI006
Anti-TL1A [L4G6] Antibody
100ug In stock
Regular Price:$306.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): Vascular endothelial growth inhibitor (VEGI), TNF superfamily member 15 (TNFSF15)
Antigen: TL1A-TNF-like ligand 1A
Accession ID: Q5UBV8
Isotype: IgG1
Clonality: Monoclonal
Clone Name: L4G6
Reactivity: Mouse
Immunogen: MTL1A-MBP (Maltose Binding Protein), Freund's complete and incomplete adjuvant
Species Immunized: Armenian Hamster
Epitope: Blocks binding to TNFRSF25
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: ELISA, FACS and Biological Function
Storage: -20C
Shipped: Cold packs

Provider
From the laboratory of Eckhard R. Podack, MD, PhD, University of Miami.
References
  1. Fang L, Adkins B, Deyev V, Podack ER. Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med. 2008 May 12;205(5):1037-48.

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