Anti-Complement Factor H, 402H [23F8] Antibody
![Anti-Complement Factor H, 402Y [23F8] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1216_2001202001263812150.jpg "Anti-Complement Factor H, 402H [23F8] Antibody")
This mouse IgG1k monoclonal antibody was generated against a synthetic peptide corresponding to human complement factor H, polymorphic variant 402-His and is specific for human complement factor H (FH-402-His).
Highlights:
- Specific for human complement factor H, polymorphic variant 402-His; reacts with purified protein and plasma
- Useful for screening for age-related macular degeneration as well as the functional characterization of complement Factor H variants
- Suitable for Western Blot applications
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.
Variants of complement pathway associated genes are significantly associated with age-related macular degeneration (AMD), the leading cause of blindness in the elderly. Most notably, the Y402H variant of human complement Factor H (FH) was identified as a common susceptibility allele and may be responsible for up to 50% of all AMD cases.
From the laboratory of Martin Oppermann, MD, University Medical Center Götingen.
This mouse IgG1k monoclonal antibody was generated against a synthetic peptide corresponding to human complement factor H, polymorphic variant 402-His and is specific for human complement factor H (FH-402-His).
Highlights:
- Specific for human complement factor H, polymorphic variant 402-His; reacts with purified protein and plasma
- Useful for screening for age-related macular degeneration as well as the functional characterization of complement Factor H variants
- Suitable for Western Blot applications
The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex.
Variants of complement pathway associated genes are significantly associated with age-related macular degeneration (AMD), the leading cause of blindness in the elderly. Most notably, the Y402H variant of human complement Factor H (FH) was identified as a common susceptibility allele and may be responsible for up to 50% of all AMD cases.
From the laboratory of Martin Oppermann, MD, University Medical Center Götingen.
| Product Type: | Antibody |
| Antigen: | Human Complement Factor H, polymorphic variant 402-His (associated with Age-related Macular Degeneration) |
| Accession ID: | P08603 |
| Isotype: | IgG1k |
| Clonality: | Monoclonal |
| Clone Name: | 23F8 |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide LENGYNQNHGRKFVQG corresponding to human complement Factor H (402-His) |
| Species Immunized: | Mouse (Balb/c) |
| Epitope: | Sequence LENGYNQNHGRKFVQG corresponding to human complement Factor H (402-His) |
| Buffer: | 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide |
| Tested Applications: | WB |
| Storage: | -20C |
| Shipped: | Cold packs |
0.4 ul plasma or 250 ng purified Factor H from blood donors homozygous for either FH-402H (FH-H) or FH-402Y (FH-Y) were separated by SDS-PAGE and probed by immunoblotting with anti-FH-H mAb 23F8, anti-FH-Y mAb 1H10 or anti-FH mAb C18/3 which reacts with both FH variants equally well.
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