This mouse IgG monoclonal antibody was generated against A431 carcinoma cells and recognizes human epidermal growth factor receptor (EGFR).
EGFR is a cell surface protein that binds to epidermal growth factor as well as transforming growth factor alpha (TGFa). It is a member of the epidermal growth factor family and is closely related to receptor tyrosine kinases. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme as well as inflammatory diseases.
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
Part of The Investigator's Annexe program.
|Accession ID:||OMIM: 131550 HGNC: 3236 Ensembl: ENSG00000146648 Entrez Gene: 1956 UniProtKB: P00533|
|Molecular Weight:||170 kDa|
|Immunogen:||A431 carcinoma cells|
|Epitope:||Epitope is not known, but closely linked to the EGF binding active site, as the antibody only recognizes the active form of EGFR|
|Tested Applications:||WB (1:1000)|
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