Anti-EGFR [425] Antibody

This mouse IgG monoclonal antibody was generated against A431 carcinoma cells and recognizes human epidermal growth factor receptor (EGFR).

Highlights:

  • Specific for human EGFR
  • Recognizes the active form of EGFR in both glycosylated and non-glycosylated EGFR
  • Suitable for Western Blot applications

EGFR is a cell surface protein that binds to epidermal growth factor as well as transforming growth factor alpha (TGFa). It is a member of the epidermal growth factor family and is closely related to receptor tyrosine kinases. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme as well as inflammatory diseases.

From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI020
Anti-EGFR [425] Antibody
100uL In Stock
Regular Price:$321.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: OMIM: 131550 HGNC: 3236 Ensembl: ENSG00000146648 Entrez Gene: 1956 UniProtKB: P00533
Antigen: EGFR
Molecular Weight: 170 kDa
Isotype: IgG
Clonality: Monoclonal
Clone Name: 425
Reactivity: Human
Immunogen: A431 carcinoma cells
Species Immunized: Mouse
Epitope: Epitope is not known, but closely linked to the EGF binding active site, as the antibody only recognizes the active form of EGFR
Buffer: Ascites
Tested Applications: WB (1:1000)
Storage: -80C
Shipped: Dry ice

Provider
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
References
  1. Murthy U, Basu A, Rodeck U, Herlyn M, Ross AH, Das M. Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide. Arch Biochem Biophys. 1987 Feb 1;252(2):549-60.

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