Anti-CD63 [ME491] Antibody

This mouse IgG monoclonal antibody was generated against clarified extract from melanoma SK Mel23 cells and recognizes human CD63.

Highlights:

  • Specific for human CD63
  • Recognizes cutaneous and uveal melanoma tissues by binding to CD63
  • Suitable for Western Blot and Immunohistochemistry applications

CD63 is a member of the tetraspanin family of surface proteins. CD63 is associated with vesicles and may localize to the cell surface. CD63 is a valuable marker for quantification of in vitro activated basophils by flow cytometry for diagnosis of IgE-mediated allergy ( this method is also known as basophil activation test (BAT). CD63 was shown to bind and internalize integrin ß2. CD63 is expressed in many tissues including testis, optic nerve, melanoma and melanocytes, etc.

From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI018
Anti-CD63 [ME491] Antibody
100ug In stock
Regular Price:$321.00
On Sale:
Specifications

Product Type: Antibody
Alternative Name(s): Granulophysin,Lysosomal-associated membrane protein 3,LAMP-3,Melanoma-associated antigen ME491,OMA81H,Ocular melanoma-associated antigen,Tetraspanin-30
Accession ID: UniProtKB: P08962 HGNC: 1692 Entrez Gene: 967 OMIM: 155740 Ensembl: ENSG00000135404
Antigen: CD63
Molecular Weight: 26 kDa
Isotype: IgG
Clonality: Monoclonal
Clone Name: ME491
Reactivity: Human
Immunogen: Clarified extract from melanoma SK Mel23 cells
Species Immunized: Mouse
Buffer: Ascites
Tested Applications: WB (1:1000), IHC (1:20)
Storage: -80C
Shipped: Dry ice

Provider
From the laboratory of Meenhard Herlyn, DVM, DSc, The Wistar Institute.
References
  1. Folberg R, Donoso LA, Atkinson BF, Ernst CS, Herlyn M, Arbizo VV. An antimelanoma monoclonal antibody and the histopathology of uveal melanomas. Arch Ophthalmol. 1985 Feb;103(2):275-9. PubMed PMID: 2579631.

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