Anti-LIMD2, N-terminal [18.3] Antibody

This mouse IgG monoclonal antibody was generated against recombinant LIM domain-containing protein 2 (LIMD2) protein and recognizes the N-terminus of human LIMD2.

Highlights:

  • Specific for human LIMD2 (N-terminal amino acids 1-127)
  • Recommended for Western Blot, Immunofluorescence, and IHC applications

LIMD2, is a protein overexpressed in metastatic lesions at higher levels by comparison to the matched primary tumor tissue. LIMD2 drives motility and invasion through binding directly to the kinase domain of integrin-linked kinase (ILK) and activating ILK signaling pathway. LIMD2 contains a classic LIM-domain structure.

From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.

The Investigator's Annexe Part of The Investigator's Annexe program.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EWI016
Anti-LIMD2, N-terminal [18.3] Antibody
100ug In stock
Regular Price:$321.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: HGNC: 28142; Entrez Gene: 80774; Ensembl: ENSG00000136490; UniProtKB: Q9BT23
Antigen: LIMD2
Molecular Weight: 14 kDa
Isotype: IgG
Clonality: Monoclonal
Clone Name: 18.3
Reactivity: Human
Immunogen: Recombinant LIMD2
Species Immunized: Mouse
Epitope: N-terminus amino acids 1-127 of human LIMD2
Purification Method: Affinity purified
Buffer: BSA/sodium azide
Tested Applications: WB, IF, IHC
Concentration: 1 mg/mL
Storage: -20C, avoid freeze thaw cycles
Shipped: Cold packs

Provider
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
References
  1. Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJ 3rd. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Res. 2014 Mar 1;74(5):1390-403. doi: 10.1158/0008-5472.CAN-13-1275.

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