This rabbit IgG polyclonal antibody was generated against a human BRCA-1 associated protein (BAP1) polypeptide and recognizes human BAP1.
BAP1 interacts with BRCA1 and interferes with BRCA1 E3 ubiquitin ligase function. BAP1 is a deubiquitinating enzyme that mediates deubiquitination of histone H2A and HCFC1. BAP1 is a tumor suppressor, it binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression and regulates of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains. BAP1 disrupts BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
|Antigen:||BAP1 (BRCA-1 associated protein)|
|Accession ID:||HGNC: 950; Entrez Gene: 8314; Ensembl: ENSG00000163930; OMIM: 603089; UniProtKB: Q92560|
|Molecular Weight:||80 kDa|
|Purification Method:||Affinity purified|
|Tested Applications:||WB (1:1000); IP (10mg per reaction)|
|Storage:||-20C, avoid freeze thaw cycles|
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