This mouse IgG1k monoclonal antibody was generated against full-length human BRCA-1 associated protein (BAP1) and recognizes human BAP1.
BAP1 interacts with BRCA1 and interferes with BRCA1 E3 ubiquitin ligase function. BAP1 is a deubiquitinating enzyme that mediates deubiquitination of histone H2A and HCFC1. BAP1 is a tumor suppressor, it binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression and regulates of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains. BAP1 disrupts BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
|Accession ID:||HGNC: 950; Entrez Gene: 8314; Ensembl: ENSG00000163930; OMIM: 603089; UniProtKB: Q92560|
|Antigen:||BAP1 (BRCA-1 associated protein)|
|Molecular Weight:||90 kDa|
|Immunogen:||Full length Human BAP1|
|Epitope:||Amino acids 337-440|
|Purification Method:||Affinity purified|
|Tested Applications:||WB (1:1000); IP (10mg per reaction) IF|
|Storage:||-20C, avoid freeze thaw cycles|
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