Anti-BAP1 [3C11] Antibody
![Anti-BAP1 [3C11] Antibody](https://www.kerafast.com/MediaStorage/Product/Images/Large/1146_2001202001263611450.jpg "Anti-BAP1 [3C11] Antibody")
This mouse IgG1k monoclonal antibody was generated against full-length human BRCA-1 associated protein (BAP1) and recognizes human BAP1.
Highlights:
- Specific for human BAP1
- Recommended for Western Blot, Immunoprecipitation, and Immunofluorescence applications
BAP1 interacts with BRCA1 and interferes with BRCA1 E3 ubiquitin ligase function. BAP1 is a deubiquitinating enzyme that mediates deubiquitination of histone H2A and HCFC1. BAP1 is a tumor suppressor, it binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression and regulates of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains. BAP1 disrupts BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
This mouse IgG1k monoclonal antibody was generated against full-length human BRCA-1 associated protein (BAP1) and recognizes human BAP1.
Highlights:
- Specific for human BAP1
- Recommended for Western Blot, Immunoprecipitation, and Immunofluorescence applications
BAP1 interacts with BRCA1 and interferes with BRCA1 E3 ubiquitin ligase function. BAP1 is a deubiquitinating enzyme that mediates deubiquitination of histone H2A and HCFC1. BAP1 is a tumor suppressor, it binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression and regulates of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains. BAP1 disrupts BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination.
From the laboratory of Frank J. Rauscher, III, PhD, The Wistar Institute.
Part of The Investigator's Annexe program.
| Product Type: | Antibody |
| Antigen: | BAP1 (BRCA-1 associated protein) |
| Accession ID: | Q92560 |
| Molecular Weight: | 90 kDa |
| Isotype: | IgGk1 |
| Clonality: | Monoclonal |
| Clone Name: | 3C11 |
| Reactivity: | Human |
| Immunogen: | Full length Human BAP1 |
| Species Immunized: | Mouse |
| Epitope: | Amino acids 337-440 |
| Purification Method: | Affinity purified |
| Buffer: | BSA/sodium azide |
| Tested Applications: | WB (1:1000); IP (10mg per reaction) IF |
| Concentration: | 1mg/mL |
| Storage: | -20C, avoid freeze thaw cycles |
| Shipped: | Cold packs |
- Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, Melnick A, Nimer SD, Jaffe JD, Aifantis I, Bernstein BE, Levine RL. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012 Aug 14;22(2):180-93. doi: 10.1016/j.ccr.2012.06.032
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