This mouse IgG2a monoclonal antibody [3E6] was generated against mouse cell line 300-19 expressing transfected human membrane-spanning 4-domains subfamily A member 8 (MS4A8B)-GFP and is specific for human extracellular MS4A8B.
MS4A (membrane-spanning 4-domain family, subfamily A) is a large family of proteins that includes at least 26 members in mouse and humans. Flanked by amino- and carboxyl- cytoplasmic regions, MS4A family members contain four highly conserved transmembrane domains connected by short extracellular and cytoplasmic loops. CD20, the most well-known MS4A family member, is a B-cell-specific molecule associated with the B cell antigen receptor and functions in receptor-activated calcium influx. Several other MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages.
From the laboratory of Julie P. Deans, PhD, University of Calgary.
Part of The Investigator's Annexe program.
|Molecular Weight:||26 kDa|
|Clone Name:||3 E6|
|Immunogen:||Mouse cell line 300-19 expressing transfected human MS4A8B-GFP|
|Purification Method:||Protein G Affinity|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||FACS (0.5 ug/106cells), IP (2ug)|
Works best for FACS on primary cells using direct staining.
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