Canine Melanoma Cell Line (CMGD-2)
CMGD-2 is a canine melanoma cell line derived from an oral tumor of a 13-year old castrated male mix breed dog.
Malignant melanoma is a type of cancer in dogs that affects pigmented-producing cells known as melanocytes. Most malignant melanomas are diagnosed in the skin and mucocutaneous junctions. They tend to grow extremely fast and are likely to spread to other organs, including the lungs and liver.
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
CMGD-2 is a canine melanoma cell line derived from an oral tumor of a 13-year old castrated male mix breed dog.
Malignant melanoma is a type of cancer in dogs that affects pigmented-producing cells known as melanocytes. Most malignant melanomas are diagnosed in the skin and mucocutaneous junctions. They tend to grow extremely fast and are likely to spread to other organs, including the lungs and liver.
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
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Specifications
| Product Type: | Cell Line |
| Name: | CMGD-2 |
| Cell Type: | Melanoma |
| Accession ID: | CVCL_0D66 |
| Morphology: | Epithelioid to spindle |
| Source: | Oral tumor (malignant melanoma) |
| Organism: | Dog |
| Biosafety Level: | 2 |
| Growth Conditions: | DMEM, 10mM HEPES, 10% FBS, 100ug/mL Primocin |
| Cryopreservation: | 90%FBS/10% DMSO |
| Mycoplasma Tested: | Yes |
| Storage: | Liquid nitrogen |
| Shipped: | Dry ice |
Provider
From the laboratory of Jaime F. Modiano, VMD, PhD, University Minnesota, Twin Cities.
References
- Bianco SR, Sun J, Fosmire SP, Hance K, Padilla ML, Ritt MG, Getzy DM, Duke RC, Withrow SJ, Lana S, Matthiesen DT, Dow SW, Bellgrau D, Cutter GR, Helfand SC, Modiano JF. Enhancing antimelanoma immune responses through apoptosis. Cancer Gene Ther. 2003 Sep;10(9):726-36.
- Milner RJ, Salute M, Crawford C, Abbot JR, Farese J. The immune response to disialoganglioside GD3 vaccination in normal dogs: a melanoma surface antigen vaccine. Vet Immunol Immunopathol. 2006 Dec 15;114(3-4):273-84. Epub 2006 Oct 5.
- Igase M, Hwang CC, Coffey M, Okuda M, Noguchi S, Mizuno T. The oncolytic effects of reovirus in canine solid tumor cell lines. J Vet Med Sci. 2015 Jun 1;77(5):541-8. doi: 10.1292/jvms.14-0570. Epub 2015 Jan 16.
- Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci. 2015 Jun 11.
- Lin W, Modiano JF, Ito D. Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci. 2017 Mar 30;18(1):101-104. doi: 10.4142/jvs.2017.18.1.101. PubMed PMID: 27456773; PubMed Central PMCID: PMC5366293.
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