This mouse IgG1 monoclonal antibody [9E8] was generated against E. coli expressed Mannose-binding protein tagged Zaire EBOV-VP24 and is specific for Zaire ebolavirus VP24 protein.
Ebola virus (EBOV), or sometimes referred to as Zaire ebolavirus is one of the five identified Ebola virus species. Zaire ebolavirus is a virological taxon that comes from the genus, Ebolvarius, family Filoviridae and the order Mononegavirales. Ebola, often fatal has been shown to cause hemorrhagic fever in humans and other mammals including monkeys and chimpanzees. Membrane-associated protein VP24 prevents the establishment of cellular antiviral state by blocking the interferon (IFN) signaling pathways. VP24 blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. VP24 plays a role in the assembly of the viral nucleocapsid and virion budding.
From the laboratory of Christopher F. Basler, PhD, Icahn School of Medicine at Mount Sinai
Part of The Investigator's Annexe program.
|Antigen:||Mannose-binding protein-tagged Zaire ebolavirus VP24 protein|
|Molecular Weight:||25 kDa|
|Clone Name:||9 E8|
|Immunogen:||E. coliexpressed Mannose-binding protein tagged Zaire EBOV-VP24|
|Purification Method:||Protein G Affinity|
|Buffer:||0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide|
|Tested Applications:||WB (1:1000)|
If you publish research with this product, please let us know so we can cite your paper.