This mouse IgG2a monoclonal antibody  was generated against sublethal infection with F. tularensis LVS and is reactive against both F. tularensis LVS and F. tularensis SchuS4 Chaperone protein DnaK.
Francisella tularensis is a small pathogenic gram-negative, nonmotile, aerobic bacteria and the causative agent of tularemia. Also known as "rabbit fever" the highly contagious bacteria can be spread from animals to humans, through a vector such as fleas or mosquitoes. F. tularensis has been considered to be encapsulated for over 40 years based on the rough colony phenotype and presence of polysachharides structures on the organism. Francisella tularensis is classified as a Category A biological agent and symptoms include fever, headache and body aches.
From the laboratory of Anne G. Savitt, PhD, Stony Brook University
Part of The Investigator's Annexe program.
|Antigen:||Chaperone protein DnaK|
|Accession ID:||Q2A328, YP_513874|
|Molecular Weight:||80 kDa|
|Reactivity:||Francisella tularensisLVS and SchuS4; cross-reacts with E. coliDnaK. Does not cross-react with DnaK from B. burgdorferior Y. pseudotuberculosis. Other species not tested.|
|Immunogen:||Sublethal infection with F. tularensisLVS|
|Purification Method:||FPLC on Protein G Sepharose|
|Method Used to Determine Concentration:||OD280 (Nanodrop)|
|Tested Applications:||WB, IP, ELISA, IF. Use at 1-10 ug/mL|
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