Jochen Walter, PhD, University of Bonn

Jochen Walter, PhD
Jochen Walter, PhD

Dr. Walter's laboratory research is focused on the functional role of genetic factors, in particular the amyloid β peptide, in the initiation and progression of neurodegeneration. The overall aim of their research is to identify pathways and molecular targets for future therapy and diagnosis.



  1. Kumar S, Wirths O, Theil S, Gerth, J, Bayer TA, Walter J. Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease. Acta Neuropathol 2013; 125: 699-709.
  2. Rijal Upadhaya A, Scheibe F, Kosterin l, Abramowski D, Gerth J, Kumar S, Liebau S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR.The type of AÃ?-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid Ã?peptide (APP48) transgenic mice. Acta Neuropathol Commun. 2013; 1:77.
  3. Rijal Upadhaya A, Kosterin l, Kumar S, von Arnim CA, Yamaguchi H, Fändrich M, Walter J, Thal DR. Biochemical stages of amyloid-� peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. Brain. 2014; 137(Pt 3):887-903.
  4. Balakrishnan K, Rijal Upadhaya A, Steinmetz J, Reichwald J, Abramowski D, Fändrich M, Kumar S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR. Impact of amyloid � aggregate maturation on antibody treatment in APP23 mice. Acta Neuropathol Commun. 2015; 3:41.