Anna Marie Pyle, PhD, Yale University

Anna Marie Pyle, PhD
Anna Marie Pyle, PhD

In the Pyle Lab, they focus on two related questions: (1) How do large RNAs assemble into specific, stable tertiary structures? (2) How is RNA recognized and remodeled by ATP-dependent enzymes in the cell? Their studies involve a combination of solution biochemistry, enzymology, crystallography, and cell-based functional approaches. In parallel, they develop new computational methods for solving, analyzing and predicting RNA structures.



  1. Zhao C, Pyle AM. Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat Struct Mol Biol. 2016 Jun;23(6):558-65.
  2. Zhao C, Liu F, Pyle AM. An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron. RNA. 2018 Feb;24(2):183-195. doi: 10.1261/rna.063479.117. Epub 2017 Nov 6. PubMed PMID: 29109157; PubMed Central PMCID: PMC5769746.