Vladimir V. Popik, PhD, University of Georgia

Vladimir V. Popik, PhD
Vladimir V. Popik, PhD

Research in the Popik lab focuses on five main areas: 1) Photoswitchable bioactive compounds; 2) Two-photon photochemistry; 3) Photolabile protecting groups; 4) Mechanisms of light-induced reactions; and 5) Photo-"click" reactions.



  1. McNitt, C. D.; Cheng, H.; Ulrich, S.; Popik, V.V.; Bjerknes, M. â??Multiphoton Activation of Photo-SPAAC 'Click' Reagents Enables In-situ Labelling with Submicron Resolutionâ? J. Am. Chem. Soc. 2017, 139(40), 14029-32, DOI: 10.1021/jacs.7b08472.
  2. Nainar, S.; Kubota, M.; McNitt, C.; Tran, C.; Popik, V. V.; Spitale, R. C. â??Temporal Labeling of Nascent RNA Using Photo-click Chemistry in Live Cellsâ? J. Am. Chem. Soc. 2017, 139(24), 8090-8093, DOI: 10.1021/jacs.7b03121.
  3. Luo, W.; Gobbo, P.; Christopher McNitt, C.D.; Sutton, D.A.; Popik, V.V.; Workentin, M.S. â??â??Shine & Click' Photoinduced Interfacial Unmasking of Strained-Alkynes on Small Water Soluble Gold Nanoparticlesâ?, Chemistry 2017, 25(5), 1052-1059, DOI: 10.1002/chem.201603398
  4. Matthew Bjerknes, Hazel Cheng, Christopher D. McNitt, and Vladimir V.Popik: Facile Quenching and Spatial Patterning of Cylooctynes via Strain-Promoted Alkyneâ??Azide Cycloaddition of Inorganic Azides. Bioconjugate Chem., 2017, 28 (5), pp 1560â??1565
  5. Orski, SV, Poloukhtine, AA, Arumugam, S, Mao, L, Popik, VV, Locklin, J: High density orthogonal surface immobilization via photoactivated copper-free click chemistry: (2010) J. of the Am. Chem. Soc. 132(32) 11024-11026
  6. Selvanathan Arumugam, Sara V. Orski, Ngalle Eric Mbua, Christopher McNitt, Geert-Jan Boons, Jason Locklin, and Vladimir V. Popik: Photo-click chemistry strategies for spatiotemporal control of metal-free ligation, labeling, and surface derivatization. Pure Appl. Chem., Vol. 85, No. 7, pp. 1499â??1513, (2013)
  7. US Patents US8,258,347, US8,426,649 and US8,541,625
  8. K. Brooks, J Yatvin, C.D. McNitt, RA Reese, C Jung, VV Popik, J Locklin: Multifunctional Surface Manipulation Using Orthogonal Click Chemistry. Langmuir, 2016, 32 (26), 6600â??6605
  9. CD McNitt, V.V. Popik, S Dhar: Copper-Free Click-Chemistry Platform to Functionalize Cisplatin Prodrugs: Chem. Eur. J., 2014, 20 (23), 6861-6865)
  10. US Patents 8,912,322
  11. Mariia V. Sutton , Matthew McKinley , Revathy Kulasekharan and Vladimir V. Popik: Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+. (2017) Chem. Commun., 53, 5598-5601