The focus of research in Dr. Naik's laboratory is to understand the molecular mechanisms of cardiovascular diseases and cancer. Cell-cell interactions and cell-extracellular matrix interactions play key roles in these diseases. Dr. Naik's research focuses on the molecular mechanisms involved in the regulation of these interactions under physiological and pathophysiological conditions, such as thrombosis, myocardial infraction, stroke, and cancer cell metastasis. Another research area of interest in Dr. Naik's lab is focused on understanding the process of tumor-induced angiogenesis. Dr. Naik has cloned a novel cell adhesion molecule, JAM-A, which is involved in platelet activation, leukocyte transmigration, and in the regulation of tight junction integrity.