Kelley W. Moremen, PhD, University of Georgia
Work in the Moremen lab is focused on four main areas: (1) characterization of mammalian glycoprotein biosynthesis and catabolism by the cloning, large-scale expression, biochemical characterization, and structure determination of the mammalian enzymes involved in these processes, (2) determination of the structural and molecular basis for the enzyme-substrate interactions for glycosidases and glycosyltransferases including mechanistic studies and identification of selective inhibitors, (3) developing technologies for detailed transcript profiling for glycan-related genes and correlating glycosylation enzyme expression with cellular glycan structures and (4) characterization of endoplasmic reticulum (ER) and Golgi enzymes involved in glycan biosynthesis and quality control degradation of misfolded nascent glycoproteins in the ER.
See Also: UGA Complex Carbohydrate Research Center (CCRC)
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References
- Moremen KW, Touster O, Robbins PW. Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme. J Biol Chem. 1991 Sep 5;266(25):16876-85.
- Velasco A, Hendricks L, Moremen KW, Tulsiani DR, Touster O, Farquhar MG. Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II. J Cell Biol. 1993 Jul;122(1):39-51.
