Daniel H. Conrad, PhD, Virginia Commonwealth University

Daniel H. Conrad, PhD
Daniel H. Conrad, PhD

The Conrad laboratory is involved in studies of the basic mechanisms of IgE-mediated allergic disease. Special attention is paid to cell surface receptors for IgE. Two general classes of these receptors are known to exist; the first, known as Fce RI, has a very high affinity for IgE and is found exclusively on mast cells and basophils. Crosslinking of FceRI causes these cells to release the mediators that cause allergy; however, the biochemical mechanisms of this mediator release process are poorly understood.

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References

  1. Keegan AD, Fratazzi C, Shopes B, Baird B, Conrad DH. Characterization of new rat anti-mouse IgE monoclonals and their use along with chimeric IgE to further define the site that interacts with Fc epsilon RII and Fc epsilon RI. Mol Immunol. 1991 Oct;28(10):1149-54.
  2. Cho S, Conrad DH. A new multivalent B cell activation model--anti-IgD bound to Fc gamma RI: properties and comparison with CD40L-mediated activation. Int Immunol. 1997 Feb;9(2):239-48.