Jim E. Cutler, PhD, Montana State University

Jim E. Cutler, PhD
Jim E. Cutler, PhD

The major interests of the Cutler lab are the immunology, biochemistry, and physiology of Candida albicans, as they contribute to the pathogenesis of infection. Our principle focus has been on the cell wall carbohydrate, and practical outcomes of our research include the development of a vaccine to prevent infection, and therapeutic antibodies that may be used to treat disseminated infections.

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References

  1. Shibata, N., K. Iuta, T. Imai, Y. Satoh, R. Satoh, A. Suzuki, C. Kojima, H. Kobayashi, K. Hisamichi and S. Suzuki, 1995. Existence of branched side chains in the cell wall mannan of pathogenic yeast, Candida albicans. Structure-antigenicity relationship between the cell wall mannans of Candida albicans and Candida parapsilosis. J.Biol.Chem. 270:1113-1122.
  2. Han, Y. and J.E. Cutler, 1995. Antibody response that protects against disseminated candidiasis. Infect.Immun. 63:2714-2719.
  3. Han, Y. and J.E. Cutler, 1997. Assessment of a mouse model of neutropenia and the effect of an anti-candidiasis monoclonal antibody in these animals. J.Infect.Dis. 175:1169-1175.
  4. Han, Y., T. Kanbe, R. Cherniak and J.E. Cutler, 1997. Biochemical characterization of Candida albicans epitopes that can elicit protective and nonprotective antibodies. Infect.Immun. 65:4100-4107.
  5. Han, Y., R.P. Morrison and J.E. Cutler, 1998. A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection. Infect.Immun. 66:5771-5776.
  6. Han, Y., M.A. Ulrich and J.E. Cutler, 1998. Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis. J.Infect.Dis. In Press.
  7. Hill, H.R., D.K. Kelsey, L.A. Gonzales and H.V. Raff, 1992. Monoclonal antibodies in the therapy of experimental neonatal group B streptococcal disease. Clin.Immunol.Immunopathol 62:87-91.
  8. Kanbe, T., Y. Han, B. Redgrave, H.H. Riesselman and J.E. Cutler, 1993. Evidence that mannans of Candida albicans are responsible for adherence of yeast forms to spleen and lymph node tissue. Infect.Immun. 61:2578-2584.
  9. Shibata, N., K. Hisamichi, T. Kikuchi, H. Kobayashi, Y. Okawa and S. Suzuki, 1992. Sequential nuclear magnetic resonance assignment of β-l,2-linked mannooligosacharides isolated from the phosophomannan of the pathogenic yeast Candida albicans NIH B-792 strain. Biochemistry 31: 5680-5686.
  10. 10. Yuan, R., A. Casadevall, G. Spira, and M.D. Scharff, 1995. Isotype switching from IgG3 to IgGl converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody. J.Immunol 154:1810-1816.
  11. Yuan, RR., G. Spira, J. Oh, M. Paizi, A. Casadevall and M.D. Scharff, 1998. Isotope switching increases efficacy of antibody protection against Cryptococcus neoformans infection in mice. Infect.Immun. 66:1057-1062.