Alison J. Quayle, PhD, Louisiana State University Health Sciences Center

Alison J. Quayle, PhD
Alison J. Quayle, PhD

The Quayle laboratory focuses on immune defense in the human female genital tract, and the mucosal immune response to HIV and the unique obligate intracellular bacteria Chlamydia trachomatis. Specific interests include: (1) Elucidation of the Chlamydia trachomatis-specific adaptive response in the human endocervix, and (2) Determination of the immunoevasive strategies used by C. trachomatis to adapt to, and survive in, the human genital milieu; (3) How C. trachomatis influences HIV transmission; (4) How female steroid hormones, particularly long-acting progestins, influence the female genital milieu and early pathogen transmission events.

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References

  1. Herbst-Kralovetz MM, Quayle AJ, Ficarra M, Greene S, Rose WA 2nd, Chesson R, Spagnuolo RA, Pyles RB. Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia. Am J Reprod Immunol. 2008 Mar;59(3):212-24.
  2. Ibana JA, Schust DJ, Sugimoto J, Nagamatsu T, Greene SJ, Quayle AJ. Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms. Infect Dis Obstet Gynecol. 2011;2011:420905
  3. Buckner LR, Schust DJ, Ding J, Nagamatsu T, Beatty W, Chang TL, Greene SJ, Lewis ME, Ruiz B, Holman SL, Spagnuolo RA, Pyles RB, Quayle AJ. Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. J Reprod Immunol. 2011 Dec;92(1-2):8-20.
  4. Ibana JA, Aiyar A, Quayle AJ, Schust DJ. Modulation of MICA on the surface of Chlamydia trachomatis-infected endocervical epithelial cells promotes NK cell-mediated killing. FEMS Immunol Med Microbiol. 2012 Jun;65(1):32-42.
  5. Radtke AL, Quayle AJ, Herbst-Kralovetz MM. Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model. Biol Reprod. 2012 Dec 6;87(6):132.
  6. Buckner LR, Lewis ME, Greene SJ, Foster TP, Quayle AJ. Chlamydia trachomatis infection results in a modest pro-inflammatory cytokine response and a decrease in T cell chemokine secretion in human polarized endocervical epithelial cells. Cytokine. 2013 Aug;63(2):151-65