Carol F. Webb, PhD, Oklahoma Medical Research Foundation

Carol F. Webb, PhD
Carol F. Webb, PhD

Dr. Webb's long-term goal has been to develop a better understanding of the molecular mechanisms involved in B lymphocyte development and antibody production. A major focus of the lab has been to understand the function of the ARID (A+T interaction domain, AT-rich interaction domain) family member ARID3a, or Bright (B cell regulator of immunoglobulin transcription), in this process. Several years ago wthey showed that Bright upregulates immunoglobulin heavy chain transcription as a member of a protein complex containing Bruton's tyrosine kinase (Btk) and the ubiquitously expressed transcription factor TFII-I. Deficiencies in Btk result in immunodeficiency disease in both mice and humans and some of her work has focused on how inhibition of Bright function may cause immunodeficiency.



  1. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF. The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 2004 Mar;228(1):42-53.
  2. Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol. 2005 Mar;25(6):2073-84.