Alexei V. Demchenko, PhD and Michael R. Nichols, PhD, University of Missouri - St. Louis

Demchenko
Alexei V. Demchenko, PhD
Nichols, PhD
Michael R. Nichols, PhD

The Demchenko and Nichols laboratories have discovered a new class of compounds that can serve as a Lipid A-like LPS antagonist and has downstream potential as a therapeutic agent for microbial sepsis. The compounds may also have effectiveness in other inflammatory disease scenarios that trigger a similar pathway.

The Investigator's Annexe Part of The Investigator's Annexe program.

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References

  1. Kaeothip S, Paranjape G, Terrill SE, Bongat AFG, Udan MLD, Kamkhachorn T, Johnson HL, Nichols MR, Demchenko AV. Development of LPS antagonistic therapeutics: synthesis and evaluation of glucopyranoside-spacer-amino acid motifs. RSC Advances, 2011, 1, 83-92.