Brian D. Brown, PhD, Icahn School of Medicine at Mount Sinai

Brian D. Brown, PhD
Brian D. Brown, PhD

The Brown lab studies the role of microRNA regulation in antigen presenting cells of the innate immune system. Through the use of novel technologies they are investigating how microRNAs influence the development and function of dendritic cells, macrophages, and other APCs. Questions they are trying to address include, understanding how microRNAs influence the response of these cells to external stimuli, such as viral and bacterial components, and disease conditions, and how microRNAs regulate the antigen presenting capacity of these cells.

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References

  1. Mullokandov G, Baccarini A, Ruzo A, Jayaprakash AD, Tung N, Israelow B, Evans MJ, Sachidanandam R, Brown BD. High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods. 2012 Jul 1;9(8):840-6.