Joel W. Hockensmith, PhD, University of Virginia

Joel W. Hockensmith, PhD
Joel Hockensmith, PhD

The Hockensmith Lab studies the molecular interactions of proteins that bind to nucleic acids to elucidate the structure-function relationships that occur during DNA metabolic processes (e.g. synthesis, repair, transcription). They are especially interested in how multiple protein complexes move along nucleic acids and recognize the particular DNA structures at which enzymatic activity occurs. In particular, they are interested in the regulation of DNA metabolic processes by DNA-dependent ATPases. These enzymes require DNA for ATP hydrolysis, which subsequently leads to alterations in DNA metabolic function.

The Investigator's Annexe Part of The Investigator's Annexe program.



  1. Mesner LD, Truman PA, Hockensmith JW. DNA-dependent adenosinetriphosphatase A: immunoaffinity purification and characterization of immunological reagents. Biochemistry 32(30): 7772-8 (1993).
  2. Mesner LD, Sutherland WM, Hockensmith JW. DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases. Biochemistry. 1991 Dec 10;30(49):11490-4. doi: 10.1021/bi00113a002. PMID: 1720977.