The Hockensmith Lab studies the molecular interactions of proteins that bind to nucleic acids to elucidate the structure-function relationships that occur during DNA metabolic processes (e.g. synthesis, repair, transcription). They are especially interested in how multiple protein complexes move along nucleic acids and recognize the particular DNA structures at which enzymatic activity occurs. In particular, they are interested in the regulation of DNA metabolic processes by DNA-dependent ATPases. These enzymes require DNA for ATP hydrolysis, which subsequently leads to alterations in DNA metabolic function.
Part of The Investigator's Annexe program.