Chemokines provide many of the directional cues for motile cells in development and adult homeostasis. This family of ~50 secreted proteins and their ~20 target G protein-coupled receptors forms a complex regulatory network that connects the innate and adaptive immune systems, serving as primary mediators of inflammation while also directing the homing and maturation of lymphocytes.
The Volkman lab uses NMR spectroscopy and a wide range of structural and functional methods to characterize protein complexes of high biomedical significance. The lab has solved 3D structures for a number of chemokines, and is currently focused on two chemokine signaling systems with unique functional roles in human immunity and disease, stromal cell-derived factor-1 (SDF-1/CXCL12) and lymphotactin/XCL1.
The following human chemokines are highly pure (> 98% by SDS-PAGE, HPLC, MALDI-MS and NMR) making them ideal for in vivo studies.
Part of The Investigator's Annexe program.