The Kapur laboratory is interested in understanding function and plasticity of inhibitory neurotransmission in the central nervous system. They are particularly interested in alterations in GABA-mediated inhibition that occur in animal models of epilepsy. Techniques used in the laboratory include EEG, patch clamp electrophysiology, immunohistochemistry, immunocytochemistry, and cellular imaging in collaboration with the Keck imaging center. Studies are carried out on whole animals, brain slices, and neuronal cultures. Recent studies have focused on trafficking of GABAA receptor during seizures and characterization of a novel form of inhibition, called tonic inhibition that is mediated by extrasynaptic GABAA receptors.
Part of The Investigator's Annexe program.