Glenn R. Gaudette, PhD and George D. Pins, PhD, Worcester Polytechnic Institute

Glenn R. Gaudette, Ph.D.
Glenn R. Gaudette, PhD
George D. Pins, Ph.D.
George D. Pins, PhD

The Gaudette and Pins labs have developed a method to produce discrete fibrin microthreads, which can be seeded with human mesenchymal stem cells (hMSCs) and used as a suture to enhance the efficiency and localization of cell delivery.

This technology is based on bioresorbable fibrin microthreads which are attached to surgical needles, allowing for the efficient delivery of cells with the same ease as employing a conventional suture. Multiple different cell types may be cultured on and delivered, offering utility for a broad array of cell therapies.

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References

  1. Guyette JP, Fakharzadeh M, Burford EJ, Tao Z, Pins GD, Rolle MW, Gaudette GR. A novel suture-based method for efficient transplantation of stem cells. Journal of Biomedical Materials Research A. 2012 Sep 8. doi: 10.1002/jbm.a.34386. [Epub ahead of print]
  2. Grasman JM, Page RL, Dominko T, Pins GD. Crosslinking strategies facilitate tunable structural properties of fibrin microthreads. 8(11)4020-4030, (2012).
  3. Proulx MK, Carey SP, Ditroia LM, Jones CM, Fakharzadeh M, Guyette JP, Clement AL, Orr RG, Rolle MW, Pins GD, Gaudette GR. Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential. Journal of Biomedical Materials Research A. 96(2): 301 - 312. 2011.
  4. Page RL, Malcuit C, Vilner L, Vojtic I, Shaw S, Hedblom E, Hu J, Pins GD, Rolle MW, Dominko T. Restoration of skeletal muscle defects with adult human cells delivered on fibrin microthreads. Tissue Eng Part A. 17(21-22):2629-2640, (2011).
  5. Cornwell KG, and Pins GD. Enhanced proliferation and migration of fibroblasts on the surface of fibroblast growth factor-2-loaded fibrin microthreads. Tissue Eng Part A. 16(12):3669-3677, (2010).
  6. Cornwell KG, Pins GD. Discrete crosslinked fibrin microthread scaffolds for tissue regeneration. Journal of Biomedical Materials Research A. 82(1):104-112, (2007).