Paulo A. Ferreira, PhD, Duke University
The focus of the Ferreira laboratory is to understand the integration of signaling and trafficking pathways and how such pathways relay environmental cues across subcellular compartments and cellular systems in mouse and disease models. Other interests include the discovery of the role of such pathway networks in the modulation of aging and disease processes leading to neurodegeneration and other human maladies. The laboratory employs two multifunctional and dynamic protein complexes assembled by two scaffold proteins to probe the processing of the integration of signaling and trafficking pathways in neuronal systems and several disease processes. They comprise the multisubunit complexes assembled by the Ran-binding protein 2 (RanBP2) and the retinitis pigmentosa GTPase regulator-interacting protein-1 (RPGRIP1).
Part of The Investigator's Annexe program.
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References
- Mavlyutov TA, Cai Y, Ferreira PA. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Traffic. 2002 Sep;3(9):630-40.
- Cho KI, Patil H, Senda E, Wang J, Yi H, Qiu S, Yoon D, Yu M, Orry A, Peachey NS, Ferreira PA. Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem. 2014 Feb 21;289(8):4600-25.
- Cho KI, Haque M, Wang J, Yu M, Hao Y, Qiu S, Pillai IC, Peachey NS, Ferreira PA. Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. PLoS Genet. 2013 Jun;9(6):e1003555.
