Human STAT3, rSTAT3-63
Recombinant human STAT3 protein, produced from E. coli.
The Signal transducer and activator of transcription 3 (STAT 3), functions as a cytoplasmic mediator of cytokine signaling and nuclear transcription factor. STAT3 is considered as one of the most crucial member of the STAT family. STAT3 activation occurs via the phosphorylation of tyrosine residue (Y705) by JAK (Janus Kinase) and serine (S727) by MAPK and non-receptor tyrosine kinases. In particular STAT 3 activity is detected in a wide variety of tumors, driving multiple pro-oncogenic functions.
Recombinant human STAT3 protein, produced from E. coli.
The Signal transducer and activator of transcription 3 (STAT 3), functions as a cytoplasmic mediator of cytokine signaling and nuclear transcription factor. STAT3 is considered as one of the most crucial member of the STAT family. STAT3 activation occurs via the phosphorylation of tyrosine residue (Y705) by JAK (Janus Kinase) and serine (S727) by MAPK and non-receptor tyrosine kinases. In particular STAT 3 activity is detected in a wide variety of tumors, driving multiple pro-oncogenic functions.
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Specifications
| Product Type: | Protein |
| Name: | Human STAT3 |
| Alternative Name(s): | Signal transducer and activator of transcription 3, STAT3 |
| Accession ID: | P40763 |
| Source: | Human Ð expressed in E. coli |
| Molecular Weight: | 63 kDa |
| Amino Acid Sequence: | VVTEKQQMLE QHLQDVRKRV QDLEQKMKVV ENLQDDFDFN YKTLKSQGDM QDLNGNNQSV TRQKMQQLEQ MLTALDQMRR SIVSELAGLL SAMEYVQKTL TDEELADWKR RQQIACIGGP PNICLDRLEN WITSLAESQL QTRQQIKKLE ELQQKVSYKG DPIVQHRPML EERIVELFRN LMKSAFVVER QPCMPMHPDR PLVIKTGVQF TTKVRLLVKF PELNYQLKIK VCIDKDSGDV AALRGSRKFN ILGTNTKVMN MEESNNGSLS AEFKHLTLRE QRCGNGGRAN CDASLIVTEE LHLITFETEV YHQGLKIDLE THSLPVVVIS NICQMPNAWA SILWYNMLTN NPKNVNFFTK PPIGTWDQVA EVLSWQFSST TKRGLSIEQL TTLAEKLLGP GVNYSGCQIT WAKFCKENMA GKGFSFWVWL DNIIDLVKKY ILALWNEGYI MGFISKERER AILSTKPPGT FLLRFSESSK EGGVTFTWVE KDISGKTQIQ SVEPYTKQQL NNMSFAEIIM GYKIMDATNI LVSPLVYLYP DIPKEE |
| Fusion Tag(s): | C-terminus 6 _ His tag |
| Format: | Lyophilized powder. Dilute to 1 mg/mL in PBS |
| Purity: | >98 %, purified by Ni NTA and determined by SDS-PAGE. |
| Buffer: | PBS |
| Tested Applications: | Drug discovery, research, cell proliferation assays |
| Comments: | Manufactured in an ISO 9001:20015 Certified Laboratory |
| Storage: | Store at -20 degree C, for extended storage |
Documentation
Provider
From the laboratory at GeNext Genomics Pvt Ltd.
References
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