Anti-SARS-CoV-2 Spike Antibodies

These mouse IgG1k monoclonal antibodes were generated against recombinant SARS-CoV-2 spike protein and recognize full-length or the RBD monomer of the spike protein.

Highlights:

  • Characterized panel of SARS-CoV-2 spike antibodies
  • All clones recongize full-length spike protein; Clones M-E5-H9, 2B-G10-A1, and 2B-E7-C9 also detect the RBD monomer
  • Suitable for ELISA applications

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The S protein is essential for both host specificity and viral infectivity. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

From the laboratories of Giuseppe A. Sautto, PhD and Ted M. Ross, PhD, University of Georgia.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EGA296
Anti-SARS-CoV-2 Spike [G8/9] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA267
Anti-SARS-CoV-2 Spike [3C-B4-F1] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA268
Anti-SARS-CoV-2 Spike [3B-B9-A4] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA269
Anti-SARS-CoV-2 Spike [M-E5-H9] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA270
Anti-SARS-CoV-2 Spike [3A-D2-B7] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA271
Anti-SARS-CoV-2 Spike [2B-G10-A1] Antibody
100ug In stock
Regular Price:$299.00
On Sale:
EGA272
Anti-SARS-CoV-2 Spike [3D-E11-F12] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA273
Anti-SARS-CoV-2 Spike [M-A8-H8] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA274
Anti-SARS-CoV-2 Spike [2B-E7-C9] Antibody
100ug In stock
Regular Price:$299.00
On Sale:
EGA275
Anti-SARS-CoV-2 Spike [3C-C4-A3] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA276
Anti-SARS-CoV-2 Spike [3D-A10-A6] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA277
Anti-SARS-CoV-2 Spike [3D-D10-A8] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA278
Anti-SARS-CoV-2 Spike [3C-C12-F9] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA279
Anti-SARS-CoV-2 Spike [3A-F2-C6] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA280
Anti-SARS-CoV-2 Spike [3B-D7-C2] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA281
Anti-SARS-CoV-2 Spike [3B-A6-B3] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA282
Anti-SARS-CoV-2 Spike [3A-C11-B2] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA283
Anti-SARS-CoV-2 Spike [3A-E12-B12] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA284
Anti-SARS-CoV-2 Spike [3D-C11-B12] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA285
Anti-SARS-CoV-2 Spike [3B-G3-C6] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA286
Anti-SARS-CoV-2 Spike [3B-G4-A2] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA287
Anti-SARS-CoV-2 Spike [3D-F6-B9] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA288
Anti-SARS-CoV-2 Spike [M-F10-D8] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA289
Anti-SARS-CoV-2 Spike [M-C7-A6] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGA290
Anti-SARS-CoV-2 Spike [3A-D12] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: QHD43416.1
Antigen: SARS-CoV-2 Spike
Molecular Weight: 210 kDa
Isotype: IgG1, k
Clonality: Monoclonal
Immunogen: Recombinant soluble trimeric SARS-CoV-2 Spike glycoprotein
Species Immunized: Mus musculus (BALB/c)
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: ELISA
Comments: All clones recongize full-length spike protein; Clones M-E5-H9, 2B-G10-A1, and 2B-E7-C9 also detect the RBD monomer
Storage: -20C
Shipped: Cold packs

Data
Cat.
Antibody
Full Length Spike EC50 (ug/mL)
Receptor Binding Domain EC50 (ug/mL)
Epitope
EGA266
G8/9
0.6716
ND
Full-length Spike
EGA267
3C-B4-F1
1.58
ND
Full-length Spike
EGA268
3B-B9-A4
2.933
ND
Full-length Spike
EGA269
M-E5-H9
2.516
6.498
RBD monomer
EGA270
3A-D2-B7
0.8746
ND
Full-length Spike
EGA271
2B-G10-A1
0.2983
0.3939
RBD monomer
EGA272
3D-E11-F12
0.3293
ND
Full-length Spike
EGA273
M-A8-H8
0.2275
ND
Full-length Spike
EGA274
2B-E7-C9
0.000345
0.2659
RBD monomer
EGA275
3C-C4-A3
0.4514
ND
Full-length Spike
EGA276
3D-A10-A6
0.4176
ND
Full-length Spike
EGA277
3D-D10-A8
1.262
ND
Full-length Spike
EGA278
3C-C12-F9
0.7009
ND
Full-length Spike
EGA279
3A-F2-C6
1.214
ND
Full-length Spike
EGA280
3B-D7-C2
0.3905
ND
Full-length Spike
EGA281
3B-A6-B3
0.3702
ND
Full-length Spike
EGA282
3A-C11-B2
0.7761
ND
Full-length Spike
EGA283
3A-E12-B12
0.4356
ND
Full-length Spike
EGA284
3D-C11-B12
0.5461
ND
Full-length Spike
EGA285
3B-G3-C6
0.4833
ND
Full-length Spike
EGA286
3B-G4-A2
1.106
ND
Full-length Spike
EGA287
3D-F6-B9
0.9416
ND
Full-length Spike
EGA288
M-F10-D8
0.2962
ND
Full-length Spike
EGA289
M-C7-A6
1.476
ND
Full-length Spike
EGA290
3A-D12
ND
ND
Full-length Spike
Provider
From the laboratories of Giuseppe A. Sautto, PhD and Ted M. Ross, PhD, University of Georgia.
References
  1. Kšppert S, Wolf C, Becza N, Sautto GA, Franke F, Kuerten S, Ross TM, Lehmann PV, Kirchenbaum GA. Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays. Cells. 2021; 10(8):1843. https://doi.org/10.3390/cells10081843

If you publish research with this product, please let us know so we can cite your paper.

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