Sun1 Antibodies

These mouse monoclonal antibodies were raised against bacterially expressed fragment (close to the Sun domain) of mouse SUN domain-containing protein 1 (Sun1) and recognize mouse SUN1.

Highlights:

  • Reacts with mouse SUN1
  • Suitable for Western Blot, Immunofluorsence and Immunocytochemistry applications

SUN (Sad1, UNC-84) domain-containing proteins are type II membrane proteins that span the inner nuclear membrane. SUN proteins interact with lamins and other proteins in the nucleoplasm and with KASH (Klarsicht, ANC-1, and Syne homology) domain-containing proteins in the perinuclear space. Since the KASH proteins span the outer nuclear membrane and interact with components of the cytoskeleton, the SUN-KASH complex, also known as the LINC complex (LInker of the Nucleoskeleton and Cytoskeleton), provides a physical link between the nuclear interior and the cytoskeleton. The LINC complex is involved in diverse cellular functions including nuclear architecture, nuclear anchorage and migration, meiotic chromosome movement and cytoskeletal organization. Not surprisingly, aberrations in the LINC complex have been associated with number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility. Sun1 is one of at least five mammalian SUN protein family members and is ubiquitously expressed. Of note, Sun1 undergoes extensive alternative splicing. Human and mouse tissues express simultaneously several isoforms with the presence and prevalence of specific isoforms being tissue dependent. The BBmSun1 X15.15 antibody is predicted to detect all the known Sun1 isoforms.

From a laboratory at Agency for Science, Technology and Research (A*STAR).

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
ESG022
Anti-Sun1 [BBmSun1 X15.15] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
ESG021
Anti-Sun1 [BBmSun1 X12.11] Antibody
100ug In stock
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Accession ID: O66837, 1193255
Antigen: Sun1
Molecular Weight: 102 kDa
Isotype: BBmSun1 X12.11: IgG2bk
BBmSun1 X15.15: IgG2ak
Clonality: Monoclonal
Clone Name: BBmSun1X12.11 or BBmSun1X15.15
Reactivity: Mouse
Immunogen: Bacterially expressed fragment (close to the Sun domain) of mouse Sun1
Species Immunized: Mouse
Purification Method: Protein G
Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications: Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry
Storage: -20C
Shipped: Cold Packs

References
  1. Crisp, M., Q. Liu, K. Roux, J.B. Rattner, C. Shanahan, B. Burke, P.D. Stahl, and D. Hodzic. 2006. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 172:41-53.
  2. Rothballer, A., T.U Schwartz, U. Kutay U. 2013. LINCing complex functions at the nuclear envelope. Nucleus. 4(1):29-36.
  3. Horn, H.F. 2014. LINC complex proteins in development and disease. Current topics in developmental biology. 109:287-321.
  4. Sosa, B.A., U. Kutay, T.U Schwartz. 2013. Structural Insights into LINC Complexes. Curr Opin Struct Biol. 23(2):285-91.
  5. Lei, K., X. Zhang, X. Ding, X. Guo, M. Chen, B. Zhu, T. Xu, Y. Zhuang, R. Xu, M. Han. 2009. SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 106(25):10207-12.

If you publish research with this product, please let us know so we can cite your paper.

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