Human Complement Protein FHR-3 (CFHR3) Antibodies

These mouse IgG1k monoclonal antibodies were raised against recombinant human complement factor H-related protein-3 (FHR-3) and recognize human FHR-3.

Highlights:

  • React with human FHR-3
  • 18A7 Binds to the SCR4-5 domain; No cross-reactivity with CFH and CFH-related proteins
  • 19E9 Binds to the SCR1-3 domain; cross-reacts with CFH
  • 18H8 Binds to CFHR3; No cross-reactivity with CFH and CFH-related proteins
  • Suitable ELISA and Immunoblot applications

The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome.

From a laboratory at University of Göttingen.

Catalog Number Product DataSheet Size AVAILABILITY Price Qty
EGO019
Anti-Complement FHR-3 (CFRH3) [18H8] Antibody
100ug 4-6 weeks
Regular Price:$299.00
On Sale:
EGO017
Anti-Complement FHR-3 (CFRH3) [18A7] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
EGO018
Anti-Complement FHR-3 (CFRH3) [19E9] Antibody
100ug Currently unavailable
Regular Price:$299.00
On Sale:
Specifications

Product Type: Antibody
Antigen: Human FHR-3
Isotype: IgG1k
Clonality: Monoclonal
Reactivity: Human
Immunogen: Recombinant human complement protein FHR-3
Species Immunized: Mouse
Myeloma Used: X63-Ag8.653
Epitope: 18A7: SCR4-5 domain; 19E9: SCR1-3 domain; 18H8: unknown
Purification Method: Protein G
Buffer: PBS, 0.05% (w/v) Sodium Azide
Tested Applications: ELISA and Immunoblot
Storage: -20C
Shipped: Cold packs

Data

Western Blot for FHR-3

Provider
From a laboratory at University of Göttingen.
Comments
18H8: Can be used for FHR-3 detection in human plasma by immunoblotting
18A7: Capture antibody in FHR-3 ELISA (together with 19E9)
19E9: Detecting antibody in FHR-3 ELISA (together with 18A7)
References
  1. Fritsche LG, Lauer N, Hartmann A, et al. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet. 2010;19(23):4694-4704. doi:10.1093/hmg/ddq399

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